USP8 protects rat-derived H9C2 cardiomyocytes from doxorubicin-triggered ferroptosis and cell death through deubiquitination-mediated stabilization of MDM4
Our findings indicate that USP8 overexpression protects H9C2 cardiomyocytes from Dox-induced ferroptosis by stabilizing MDM4 via deubiquitination.
Authors
- Liang Zhang (ORCID: https://orcid.org/0000-0002-8726-1128)
- Xue Yang (ORCID: https://orcid.org/0000-0003-1965-0399)
- Y.Y Li
Institutions
- Sir Run Run Shaw Hospital (CN)
- Tongde Hospital of Zhejiang Province (CN)
Publication Details
- Journal
- Hereditas
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1186/s41065-025-00527-z
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52