Chronic and reactivated dengue infection in an immunocompromised host: insights from a case report

This case highlights the rare but clinically relevant possibility of chronic dengue infection in immunocompromised patients. The confirmed persistence of the same viral strain over nearly three years challenges the conventional view of dengue as a strictly acute infection. It raises concern about the potential for reintroduction and re-emergence of previously circulating strains, as well as the detrimental tissue consequences of chronic infection by the virus. These findings have important implications for clinical management, diagnostic strategies, and public health surveillance, and underscore the need for further research to better understand the mechanisms of dengue chronicity-particularly those involving viral immune evasion and host immune dysfunction.