Acupuncture improves perimenopausal depression via a mechanism involving activation of the phosphatidylinositol 3-kinase/serine-threonine protein kinase/mechanistic target of rapamycin pathway in a rat model
Acupuncture alleviates PMD through dual regulation of sex hormone homeostasis and activation of the PI3K/AKT/mTOR pathway, suggesting a potential mechanism for its antidepressant effects in perimenopause.
Authors
- Si Liang Yao
- Chenghao Liu (ORCID: https://orcid.org/0000-0001-7923-6806)
- Zhanling Sun
- Lifang Zheng (ORCID: https://orcid.org/0009-0003-5825-6412)
- Yabei Jin
Institutions
- Zhejiang Chinese Medical University (CN)
- Integrated Chinese Medicine (China) (HK)
Publication Details
- Journal
- Neuroreport
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1097/wnr.0000000000002210
- Citations
- 1
- Primary Topic
- Menopause: Health Impacts and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.29