Outcomes of relapsed/refractory peripheral T-cell lymphoma in the modern era: impact of stem cell transplant and novel agents
Peripheral T-cell lymphoma (PTCL) is characterized by clinicopathologic heterogeneity with a frequently relapsing/refractory (R/R) course. The optimal sequencing and efficacy of novel agents and SCT in second-line and beyond remains yet to be determined. The objective of this dual-institution retrospective study is to assess outcomes in R/R nodal PTCL with respect to SCT and novel agents. A total of 148 patients were reviewed for baseline characteristics and treatment parameters. Endpoints were subsequent EFS (sEFS) and subsequent overall survival (sOS). The median sEFS and sOS for the entire cohort was 5.3 m (95% CI: 4.1 - 7.1) and 32.4 m (95% CI: 17.7 - 71.0), respectively. The median sEFS favored patients who received salvage SCT following either chemotherapy or novel agents (<i>p</i> = 0.005). The median sOS showed similar trend. Altogether, these data suggest that incorporation of novel agents in patients with and without SCT in second-line and beyond may improve outcomes compared to historical cohorts.
Authors
- Hua-Jay Jeffery Cherng (ORCID: https://orcid.org/0000-0002-8266-8447)
- Giorgio Inghirami (ORCID: https://orcid.org/0000-0001-5566-0864)
- Ahmed Sawas (ORCID: https://orcid.org/0000-0003-2448-0144)
- Barbara Pro
- Madhav Seshadri
- Caitlin Gribbin
- Koen van Besien (ORCID: https://orcid.org/0000-0002-8164-6211)
- Adrienne A. Phillips (ORCID: https://orcid.org/0000-0003-2024-3483)
- Jia Ruan
- Evelyn Orlando
- Seda S. Tolu (ORCID: https://orcid.org/0000-0003-2235-4902)
- Tsiporah B. Shore (ORCID: https://orcid.org/0000-0001-6033-0747)
- Jennifer E. Amengual (ORCID: https://orcid.org/0000-0003-4117-2469)
- Alexander Sanjurjo (ORCID: https://orcid.org/0000-0002-6890-5717)
- Justin E. Grenet (ORCID: https://orcid.org/0000-0001-8177-4531)
- Zhengming Chen (ORCID: https://orcid.org/0000-0001-9437-6452)
- Rajbir Toor
- Peter W. Martin
- John P. Leonard
Institutions
- Cornell University (US)
- Columbia University Irving Medical Center (US)
- College Medical Center (US)
- Weill Cornell Medical College in Qatar (QA)
- Sylvester Comprehensive Cancer Center (US)
Publication Details
- Journal
- Leukemia & lymphoma/Leukemia and lymphoma
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1080/10428194.2025.2540437
- Citations
- 1
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47