Protein modifications by advanced glycation end products (AGEs) in human clear cell renal cell carcinoma
This study demonstrates a distinct AGE-modified proteome in ccRCC compared to non-tumor tissue, with modifications frequently occurring within or near functional domainst. Therefore, further investigation into the mechanisms underlying AGE-protein adduct formation in renal carcinogenesis could help in understanding ccRCC development.
Authors
- Agnieszka Gęgotek (ORCID: https://orcid.org/0000-0002-5240-1346)
- Neven Žarković (ORCID: https://orcid.org/0000-0001-5032-0369)
- Robert Kozłowski
- Paweł Samocik
- Elźbieta Skrzydlewska (ORCID: https://orcid.org/0000-0001-5397-7139)
- H Ostrowska (ORCID: https://orcid.org/0000-0003-0706-8270)
- Mariusz Koda (ORCID: https://orcid.org/0000-0002-1678-567X)
- Justyna Brańska‐Januszewska
Institutions
- Medical University of Białystok (PL)
- Ruđer Bošković Institute (HR)
- Wojewódzki Szpital Zespolony im. Jędrzeja Śniadeckiego (PL)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1186/s12967-025-06958-6
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.00