Transcriptome profiling and weighted gene co-expression network analysis reveal changes of hub genes and molecular pathways in rat lungs following deep hypothermic circulatory arrest
DHCA significantly altered gene expression patterns in rat lung tissues. The identified hub genes and signaling pathways related to inflammation and apoptosis may serve as potential therapeutic targets for lung injury following DHCA.
Authors
- Qiong Wu (ORCID: https://orcid.org/0009-0002-8146-3199)
- Guodong Zhong (ORCID: https://orcid.org/0000-0002-0942-4497)
- Liangwan Chen (ORCID: https://orcid.org/0000-0002-8317-7412)
- Lei Wang (ORCID: https://orcid.org/0000-0002-4001-6387)
- Yu‐Ping Lin
- Zhuangbin Lin
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Fujian Medical University (CN)
- Fuzhou Second Hospital (CN)
- Union Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1371/journal.pone.0328887
- Citations
- 1
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.81