Mechanisms of Activation and Serotonin Release From Human Enterochromaffin Cells
5-HT release from EC cells controls many physiological functions and is currently being targeted to treat disorders of the gut-brain axis. Studying ECs from human organoids enables improved understanding of the molecular mechanisms underlying EC cell activation, which is fundamental for the development of new strategies to target 5-HT-related gut and metabolic disorders.
Authors
- Adam Davison
- Fiona M. Gribble (ORCID: https://orcid.org/0000-0002-4232-2898)
- Megan Hodge
- Constanza Alcaino (ORCID: https://orcid.org/0000-0001-9595-4330)
- Ahmed Shaaban (ORCID: https://orcid.org/0000-0002-5145-3857)
- Cordelia Imig (ORCID: https://orcid.org/0000-0001-7351-8706)
- Frank M. Reimann (ORCID: https://orcid.org/0000-0001-9399-6377)
- Rula Bany Bakar (ORCID: https://orcid.org/0000-0002-5643-0195)
- Richard G. Kay (ORCID: https://orcid.org/0000-0002-3827-8687)
- Tianyi Lu
- Nunzio Guccio
- Emily L. Miedzybrodzka (ORCID: https://orcid.org/0000-0001-9201-0860)
- Christopher A. Smith (ORCID: https://orcid.org/0000-0001-6478-2310)
- Jaden R Quale
- Emily Overington
- Mae Tabbada
Institutions
- University of Copenhagen (DK)
- Copenhagen University Hospital (DK)
- Wellcome/MRC Institute of Metabolic Science (GB)
- Addenbrooke's Hospital (GB)
- MRC Epidemiology Unit (GB)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101610
- Citations
- 3
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 5.43
Funders
- Cancer Research UK
- Lundbeckfonden
- H. Lundbeck A/S
- Medical Research Council
- Cambridge Institute for Medical Research, University of Cambridge
- Cancer Research UK Cambridge Institute, University of Cambridge