Improved Resolution of Influenza Vaccination Responses With High‐Throughput Live Virus Microneutralisation
Our high-throughput method offers an alternative approach to assess influenza-specific serological responses with improved resolution, with the potential to improve the annual assessment of existing antibody landscapes, to improve new vaccine strain evaluation, and to offer a step-change in systems vaccinology, and a facet of laboratory-based pandemic preparedness.
Authors
- James Bazire (ORCID: https://orcid.org/0000-0002-7094-5021)
- Annabel Borg (ORCID: https://orcid.org/0000-0003-2873-7226)
- Christine Carr
- Callie Smith (ORCID: https://orcid.org/0000-0001-9147-951X)
- Silvia Innocentin (ORCID: https://orcid.org/0009-0005-0136-0678)
- Ruth Harvey (ORCID: https://orcid.org/0000-0002-1428-9621)
- Edward J Carr (ORCID: https://orcid.org/0000-0001-9343-4593)
- Lorin Adams (ORCID: https://orcid.org/0000-0001-8357-2327)
- Chloë Roustan (ORCID: https://orcid.org/0000-0002-8439-8997)
- Nicola S. Lewis (ORCID: https://orcid.org/0000-0001-9496-4756)
- Louise M. C. Webb (ORCID: https://orcid.org/0000-0003-3417-1484)
- Phoebe Stevenson-Leggett (ORCID: https://orcid.org/0000-0002-6509-3354)
- Nicola O’Reilly (ORCID: https://orcid.org/0000-0002-4204-6491)
- Jia Le Lee (ORCID: https://orcid.org/0000-0002-1600-6437)
- Michelle A. Linterman (ORCID: https://orcid.org/0000-0001-6047-1996)
- Mary Wu (ORCID: https://orcid.org/0000-0002-2074-6171)
- Agnieszka Hobbs
- Giulia Dowgier (ORCID: https://orcid.org/0000-0001-6738-5097)
- Svend Kjær (ORCID: https://orcid.org/0000-0001-9767-8683)
Institutions
- Babraham Institute (GB)
- The Francis Crick Institute (GB)
- The Royal Free Hospital (GB)
- University College London (GB)
Publication Details
- Journal
- Influenza and Other Respiratory Viruses
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1111/irv.70140
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Pennsylvania
- Wellcome Trust
- Francis Crick Institute
- UK Research and Innovation
- Cancer Research UK
- National Institute for Health and Care Research
- University of Cambridge
- Lister Institute of Preventive Medicine
- Cambridge University Hospitals
- National Institutes of Health
- Directorate for Biological Sciences
- Medical Research Council
- NIHR Cambridge Biomedical Research Centre