N-glycans in lung tissue specimens: a prospective target for enhanced cancer diagnosis and prognosis
The results imply distinct glycosylation patterns even in patients with the same histological type of lung cancer, supporting trends toward personalized diagnosis and more tailored therapies. Currently, tissue biopsies remain the gold standard for diagnosing premalignant and malignant lesions in the lung. Expanded knowledge on glycosylation in these lesions could contribute to improved diagnostic accuracy and better monitoring of malignant disease progression in clinical practice.
Authors
- Jitka Hausnerová (ORCID: https://orcid.org/0000-0002-0522-1916)
- Zbyněk Zdráhal (ORCID: https://orcid.org/0000-0003-3044-5548)
- Karolína Kryštofová
- Jana Skřičková
- Leoš Křen (ORCID: https://orcid.org/0000-0002-9509-1552)
- Erika Lattová (ORCID: https://orcid.org/0000-0002-8221-6141)
- Mikuláš Popovič
Institutions
- University of Maryland, Baltimore (US)
- Central European Institute of Technology (CZ)
- Masaryk University (CZ)
- Central European Institute of Technology (AT)
- Institute of Human Virology (NG)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1186/s12967-025-06904-6
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerstvo Školství, Mládeže a Tělovýchovy