Cyclodextrin-mediated Enhancement of Haloperidol Solubility: Physicochemical Studies and In Vivo Investigation Using Planaria Worms
Cyclodextrins, particularly α-CD, methyl-β-CD, and hydroxypropyl-β-CD, effectively enhance the solubility of haloperidol by forming 1:1 inclusion complexes. The reduction in haloperidol-induced behavioral changes in planaria by CDs suggests a potential impact on drug bioavailability and supports the use of planaria as a simple in vivo model for screening neuroactive compounds and formulations.
Authors
- Vitaliy V. Khutoryanskiy
- Yong Xiong (ORCID: https://orcid.org/0000-0001-9625-9313)
- Kenneth Shankland (ORCID: https://orcid.org/0000-0001-6566-0155)
Institutions
- University of Reading (GB)
Publication Details
- Journal
- Pharmaceutical Research
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1007/s11095-025-03909-0
- Primary Topic
- Chemical synthesis and alkaloids
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Royal Society
- University of Reading