Data from multi-national aging cohorts show dysregulated metabolic pathways in people with physio-cognitive decline
This study defines the comprehensive metabolomic signature of PCD, revealing disrupted metabolic pathways and identifying promising biomarker candidates for early detection and monitoring of physio-cognitive decline in aging populations.
Authors
- Chih‐Kuang Liang (ORCID: https://orcid.org/0000-0003-1604-1600)
- Luigi Ferrucci (ORCID: https://orcid.org/0000-0002-6273-1613)
- Wei‐Ju Lee (ORCID: https://orcid.org/0000-0003-4326-333X)
- Wei‐Ju Chang (ORCID: https://orcid.org/0000-0003-0524-4883)
- Rei Otsuka (ORCID: https://orcid.org/0000-0001-6184-570X)
- Chao‐Hsiung Lin (ORCID: https://orcid.org/0000-0001-6344-271X)
- Hidenori Arai (ORCID: https://orcid.org/0000-0001-6747-8680)
- Yukiko Nishita (ORCID: https://orcid.org/0000-0002-2551-9605)
- Yi‐Long Huang (ORCID: https://orcid.org/0000-0002-0980-4828)
- Liang‐Kung Chen (ORCID: https://orcid.org/0000-0002-2387-8508)
- Shu Zhang (ORCID: https://orcid.org/0000-0003-3658-3159)
- Li‐Ning Peng (ORCID: https://orcid.org/0000-0003-1308-9553)
- Ming‐Yueh Chou
Institutions
- National Yang Ming Chiao Tung University (TW)
- Taipei Veterans General Hospital (TW)
- National Institute on Aging (US)
- Kaohsiung Veterans General Hospital (TW)
- National Center for Geriatrics and Gerontology (JP)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1038/s43856-025-01073-5
- Citations
- 3
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Shanghai Educational Development Foundation
- National Health Research Institutes
- National Science and Technology Council