Predictive Value of Nervous Cell Injury Biomarkers in Moderate-to-Severe Traumatic Brain Injury
Our findings suggest that S100B, GFAP, NSE, and UCH-L1 have predictive value for mortality and functional outcomes in moderate/severe TBI. NSE was the most effective biomarker for predicting mortality. By contrast, UCH-L1 ranked highest for predicting unfavorable functional outcomes. Further research is needed to standardize protocols for measuring/providing data on biomarkers and to integrate them into predictive models for clinical use.
Authors
- W. Dalton Dietrich (ORCID: https://orcid.org/0000-0002-8732-4942)
- Kristine O’Phelan (ORCID: https://orcid.org/0000-0002-5074-1232)
- Fernanda J.P. Teixeira (ORCID: https://orcid.org/0000-0001-8646-9624)
- Amedeo Merenda (ORCID: https://orcid.org/0000-0002-9270-7470)
- Mohan Kottapally (ORCID: https://orcid.org/0000-0003-4377-2409)
- Robert W. Keane (ORCID: https://orcid.org/0000-0003-4068-9511)
- Ayham M. Alkhachroum (ORCID: https://orcid.org/0000-0003-0352-5913)
- Brian Manolovitz (ORCID: https://orcid.org/0009-0002-7348-5187)
- Nina Massad (ORCID: https://orcid.org/0009-0004-4818-8337)
- Lilian Maria Godeiro Coelho (ORCID: https://orcid.org/0009-0002-7902-8999)
- Tulay Koru‐Sengul (ORCID: https://orcid.org/0000-0003-0974-8405)
- Ruby Rose Taylor
- Juan Pablo de Rivero Vaccari (ORCID: https://orcid.org/0000-0002-5460-8834)
- Jennifer C. Muñoz Pareja (ORCID: https://orcid.org/0000-0001-5647-0579)
Institutions
- University of Miami (US)
- Jackson Memorial Hospital (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1212/wnl.0000000000213997
- Citations
- 6
- Primary Topic
- Traumatic Brain Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 8.13