Plasma proteomic analysis identifies proteins and pathways related to Alzheimer's risk
Plasma proteins were identified as being associated with Alzheimer's disease (AD) and plasma biomarkers. The identified proteins were replicated in both plasma and cerebrospinal fluid (CSF) proteomics. The identified proteins were associated with AD biomarker-specific pathways. The identified proteins improved the performance of the AD classification. Protein network analysis identified network modules and their enriched pathways.
Authors
- Frederick W. Unverzagt (ORCID: https://orcid.org/0000-0001-9297-1186)
- Donna M. Wilcock (ORCID: https://orcid.org/0000-0003-3388-1564)
- Shannon L. Risacher (ORCID: https://orcid.org/0000-0002-3304-7943)
- Sophia Wang (ORCID: https://orcid.org/0000-0003-2597-9393)
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- Andrew J. Saykin (ORCID: https://orcid.org/0000-0002-1376-8532)
- Lindsey A. Kuchenbecker (ORCID: https://orcid.org/0000-0002-2987-1040)
- Liana G. Apostolova (ORCID: https://orcid.org/0000-0003-1823-2451)
- Tamina Park
- Sujuan Gao (ORCID: https://orcid.org/0000-0002-6741-6380)
- Carlos C Cruchaga (ORCID: https://orcid.org/0000-0002-0276-2899)
- Jeffrey L. Dage (ORCID: https://orcid.org/0000-0002-2192-1699)
- Kristen A. Russ
- Minerva M. Carrasquillo (ORCID: https://orcid.org/0000-0002-3231-9134)
- Paula J. Bice (ORCID: https://orcid.org/0000-0001-5357-9966)
- Kelly Nudelman (ORCID: https://orcid.org/0000-0003-4040-1717)
- Sunu Mathew (ORCID: https://orcid.org/0000-0003-4958-5575)
- Martin R. Farlow (ORCID: https://orcid.org/0000-0001-7897-5471)
- Soumilee Chaudhuri (ORCID: https://orcid.org/0000-0002-8488-6114)
- Jared R. Brosch (ORCID: https://orcid.org/0000-0002-6578-0584)
- Nilüfer Ertekin‐Taner (ORCID: https://orcid.org/0000-0003-4436-8889)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Kwangsik Nho
- David G. Clark
- Yen-Ning Huang (ORCID: https://orcid.org/0009-0003-4872-231X)
- Tatiana Foroud
- Shiwei Liu
Institutions
- University of Science and Technology of China (CN)
- Indiana University Health (US)
- Mayo Clinic (US)
- University of Wisconsin–Madison (US)
- Washington University in St. Louis (US)
- Sahlgrenska University Hospital (SE)
- Jacksonville College (US)
- Sorbonne Université (FR)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- Mayo Clinic in Florida (US)
- National Hospital for Neurology and Neurosurgery (GB)
- Institut du Cerveau (FR)
- Indiana University Indianapolis (US)
- Indiana University School of Medicine
- University College London (GB)
- Indiana University – Purdue University Indianapolis (US)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/alz.70579
- Citations
- 4
- Primary Topic
- Biological Research and Disease Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- European Commission
- Vetenskapsrådet
- HORIZON EUROPE Framework Programme
- National Institute on Aging