Proton Pump Inhibitor Use and Risk of Hepatic Encephalopathy in Cirrhotic Patients: A Systematic Review and Meta-analysis
This meta-analysis supports a potential association between PPI use and an increased risk of hepatic encephalopathy in cirrhotic patients. These findings underscore the importance of cautious and judicious use of PPIs in this vulnerable population, reserving them for clear clinical indications.
Authors
- Meagan J. Stotts
- Sandra Chehayeb
- Nader Al Souky (ORCID: https://orcid.org/0000-0001-6579-396X)
- William J. Salyers (ORCID: https://orcid.org/0000-0001-6666-5484)
- Hayrettin Okut (ORCID: https://orcid.org/0000-0003-4084-8404)
- Janane Nasr
- Hasan Jaber
- Daly Al Hadeethi
Institutions
- University of Kansas (US)
- Wichita State University (US)
Publication Details
- Journal
- Clinics and Research in Hepatology and Gastroenterology
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1016/j.clinre.2025.102667
- Citations
- 3
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 3.97