Secondary Metabolites of <i>Mansonia gagei</i> and Their Potential Anti‐dengue Properties

Three undescribed compounds, including compounds 1 and 2 with a bicyclo[3.2.1]octane skeleton, along with a coumarin derivative (compound 3) and seven known compounds (4-10), were isolated from the heartwood of Mansonia gagei. To our knowledge, compounds 6-8 are reported for the first time from the Mansonia genus. The structures of these compounds were determined through high-resolution electrospray ionization mass spectrometry, nuclear magnetic resonance spectroscopic analysis, and density functional theory calculations. The antiviral activity of isolated compounds was assessed against dengue virus serotype DENV1, indicating that compound 2 exhibited potent anti-dengue activity with a 50% Plaque Reduction Neutralization Test value of 17.47 µM.

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Publication Details

Journal
Chemistry & Biodiversity
Published
2025-08-14
DOI
https://doi.org/10.1002/cbdv.202500951
Primary Topic
Traditional and Medicinal Uses of Annonaceae
Type
article
Field-Weighted Citation Impact
0.00

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article

Secondary Metabolites of Mansonia gagei and Their Potential Anti‐dengue Properties

Truong L. Tuong, Yusuke Hioki, Thi‐Anh‐Tuyet Le, Vu Thi Bich Hau et al.
Chemistry & Biodiversity
Traditional and Medicinal Uses of Annonaceae
article

Secondary Metabolites of Mansonia gagei and Their Potential Anti‐dengue Properties

Truong L. Tuong, Yusuke Hioki, Thi‐Anh‐Tuyet Le, Vu Thi Bich Hau, Warinthorn Chavasiri, Thanh‐Hoa Vo, Masaki Kita, Huong Thi Thu Le, Nguyễn Thị Thu Thủy, Thi Kha Uyen Tran
article en

Abstract

Three undescribed compounds, including compounds 1 and 2 with a bicyclo[3.2.1]octane skeleton, along with a coumarin derivative (compound 3) and seven known compounds (4-10), were isolated from the heartwood of Mansonia gagei. To our knowledge, compounds 6-8 are reported for the first time from the Mansonia genus. The structures of these compounds were determined through high-resolution electrospray ionization mass spectrometry, nuclear magnetic resonance spectroscopic analysis, and density functional theory calculations. The antiviral activity of isolated compounds was assessed against dengue virus serotype DENV1, indicating that compound 2 exhibited potent anti-dengue activity with a 50% Plaque Reduction Neutralization Test value of 17.47 µM.

Chemistry & BiodiversityVol. 22(12)
Vietnam National University Ho Chi Minh City (VN), Chulalongkorn University (TH), University of Medicine and Pharmacy at Ho Chi Minh City (VN), Ho Chi Minh City University of Education (VN), National Institute Of Hygiene And Epidemiology (VN), Nagoya University (JP)
Viet Nam National University Ho Chi Minh City, Information Technology Center, Nagoya University
Openalex Percentile: Top 80%
Traditional and Medicinal Uses of Annonaceae
DOIOpen Access PDFOpenAlex
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