Molecular Portraits of Social Adversity in Breast Cancer: Neighborhood Disadvantage Is Associated with Epigenetic Deregulation of Key Oncogenic Pathways
This study demonstrates that ND, which is associated with shorter breast cancer survival, is also associated with epigenetic reprogramming of key oncogenesis pathways. These findings highlight pathways through which ND may affect tumor biology and lay the foundation for cancer control policy and behavioral interventions that may reverse the negative effects of ND on cancer biology.
Authors
- Peter D. Lyon (ORCID: https://orcid.org/0000-0002-0226-7425)
- Susan B. Kesmodel (ORCID: https://orcid.org/0000-0003-0010-6078)
- María E. Figueroa (ORCID: https://orcid.org/0000-0003-4887-4981)
- Alexandra Hernández (ORCID: https://orcid.org/0000-0003-3508-0189)
- Eantiago Hernández (ORCID: https://orcid.org/0009-0003-7517-251X)
- Nipun B. Merchant (ORCID: https://orcid.org/0000-0002-3399-9776)
- Neha Goel (ORCID: https://orcid.org/0000-0003-0357-4109)
- Luisa Cimmino (ORCID: https://orcid.org/0000-0002-4218-582X)
- Aristeidis G. Telonis (ORCID: https://orcid.org/0000-0003-1575-2769)
- Lluís Morey (ORCID: https://orcid.org/0000-0001-9851-4066)
- Monica Yepes (ORCID: https://orcid.org/0000-0002-5936-5851)
- Fernando Collado‐Mesa (ORCID: https://orcid.org/0000-0003-0489-3566)
- Jose Net (ORCID: https://orcid.org/0009-0001-4462-4398)
- Liliana Garcia-Martinez (ORCID: https://orcid.org/0000-0002-3015-5543)
- Peter Borowsky (ORCID: https://orcid.org/0000-0002-7185-2417)
- Melinda Boone (ORCID: https://orcid.org/0000-0003-3463-4688)
- Erin N. Kobetz (ORCID: https://orcid.org/0000-0001-9215-5525)
- Mengsheng Zha (ORCID: https://orcid.org/0009-0006-8448-1850)
Institutions
- University of Miami (US)
- Thomas Jefferson University (US)
- University of Miami Health System (US)
- University of Miami Hospital (US)
- Sylvester Comprehensive Cancer Center (US)
Publication Details
- Journal
- Cancer Epidemiology Biomarkers & Prevention
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1158/1055-9965.epi-25-0123
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00