Alpha‐Ketoisocaproate Attenuates Muscle Atrophy in Cancer Cachexia Models
Our findings demonstrate that KIC improves muscle function in CAC-induced muscle atrophy by regulating myostatin expression in skeletal muscle via the Akt-FoxO3a pathway. Thus, KIC has been proposed as a potential therapeutic agent against CAC.
Authors
- Jihye Han
- Jae Ho Shim (ORCID: https://orcid.org/0000-0001-9861-6521)
- Ji Wook Moon (ORCID: https://orcid.org/0000-0003-1384-1469)
- Pooreum Lim (ORCID: https://orcid.org/0009-0004-4209-4591)
- Jeong Hyeon Kim
- Jeong Min Nam
- Donghun Kim (ORCID: https://orcid.org/0000-0001-5441-1532)
- Hyeon Soo Kim
- Jaehoon Lim
- Yujun Kang
- Seung-Hwan Woo (ORCID: https://orcid.org/0009-0006-4759-0564)
- Young Lim Lee (ORCID: https://orcid.org/0009-0009-6469-3065)
Institutions
- Korea University (KR)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/jcsm.70044
- Citations
- 1
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 1.16