Real-world outcomes in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia or chronic myeloid leukemia treated with ponatinib – final 6-year results from a Belgian registry
In line with previously published trials, these real-world data support use of ponatinib in CML and Ph+ ALL patients with resistance or intolerance to previous TKIs or carrying the <i>T315I</i> mutation.<b>Trial registration:</b> ClinicalTrials.gov identifier: NCT03678454; September 19, 2018.
Authors
- Marie Lejeune (ORCID: https://orcid.org/0000-0001-5620-8052)
- Ann Van de Velde (ORCID: https://orcid.org/0000-0002-4579-2916)
- Hinde Sebti
- Nikki Granacher
- Alain Gadisseur (ORCID: https://orcid.org/0000-0001-9419-8772)
- Dominik Selleslag
- Gaëtan Vanstraelen
- Inge Vrelust
- Dries Deeren (ORCID: https://orcid.org/0000-0001-9599-2142)
- A. Triffet
- Fleur Samantha Benghiat (ORCID: https://orcid.org/0000-0002-2521-238X)
- Koen Theunissen
- Benjamin Bailly (ORCID: https://orcid.org/0000-0003-0782-2325)
- Stef Meers
- Dominiek Mazure
- Violaine Havelange (ORCID: https://orcid.org/0000-0001-6061-6315)
- Ann Becker (ORCID: https://orcid.org/0000-0003-4892-9727)
- Hélène Vellemans
- Timothy Devos (ORCID: https://orcid.org/0000-0002-6881-417X)
- Philippe Lewalle (ORCID: https://orcid.org/0009-0005-6483-9782)
- Mia Janssen
- M. H. Beck
Institutions
- Cliniques Universitaires Saint-Luc (BE)
- Université Libre de Bruxelles (BE)
- Vrije Universiteit Brussel (BE)
- Rega Institute for Medical Research (BE)
- Ghent University Hospital (BE)
- Institut Jules Bordet (BE)
- Erasmus Hospital (BE)
- CHU Dinant Godinne UCL Namur (BE)
- AZ Klina (BE)
- Jessa Hospital (BE)
- Genias Benelux (Netherlands) (NL)
- Alrijne Ziekenhuis (NL)
- Antwerp University Hospital (BE)
- Hôpital de Jolimont (BE)
- AZ Sint-Jan (BE)
- Universitair Ziekenhuis Brussel (BE)
- AZ Turnhout (BE)
- CHR Verviers (BE)
- Centre Hospitalier Universitaire de Liège (BE)
- Groene Hart Ziekenhuis (NL)
- AZ Delta (BE)
- Ziekenhuis Oost-Limburg (BE)
- Ziekenhuisnetwerk Antwerpen Stuivenberg (BE)
- Grand Charleroi Hospital (BE)
- Incyte (United States) (US)
- KU Leuven (BE)
Publication Details
- Journal
- Hematology
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1080/16078454.2025.2534196
- Citations
- 1
- Primary Topic
- Chronic Myeloid Leukemia Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- Incyte