Human Pluripotent Stem Cell‐Derived Skeletal Muscle Organoid Model of Aging‐Induced Sarcopenia
We successfully developed a hSkMOs to demonstrate the structural maturity of the skeletal muscle and its functional interaction with spinal-derived interneurons and motor neurons. Furthermore, we demonstrated that our hSkMOs are useful for modelling aging-induced sarcopenia and providing a valuable platform for testing therapeutic interventions.
Authors
- Jeoung Eun Lee
- Ji Young Mun (ORCID: https://orcid.org/0000-0003-0820-6233)
- M. Kim (ORCID: https://orcid.org/0000-0002-1885-881X)
- Yongjung Park (ORCID: https://orcid.org/0000-0001-5668-4120)
- Yeo Jin Kim (ORCID: https://orcid.org/0000-0002-1008-7459)
- Su Bin Lim (ORCID: https://orcid.org/0000-0003-1752-7039)
- Xin Yi Yeo (ORCID: https://orcid.org/0000-0003-1546-4564)
- Muhammad Junaid (ORCID: https://orcid.org/0000-0002-0675-5864)
- Soo‐Jeong Park
- Junghyun Jo (ORCID: https://orcid.org/0000-0001-8439-4155)
- Sangyong Jung (ORCID: https://orcid.org/0000-0003-3017-1145)
- Min Kyoung Shin (ORCID: https://orcid.org/0000-0003-0459-4937)
- Shensheng Gu (ORCID: https://orcid.org/0000-0002-8228-8751)
- Dong Ryul Lee
- Dong Seok Jeong
Institutions
- National University of Singapore (SG)
- CHA University Bundang Medical Center (KR)
- CHA University (KR)
- Korea Brain Research Institute (KR)
- Ajou University (KR)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/jcsm.70045
- Citations
- 2
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Research Foundation of Korea