Research progress in gene editing technologies and their applications in aging-related genes

This paper reviews the latest advances and applications of gene editing technologies in the study of aging-related genes. In recent years, gene editing has achieved significant progress in the biomedical field, with continual improvements in accuracy and efficiency. Gene editing technologies demonstrate unique advantages in aging research, providing powerful tools for elucidating aging mechanisms and developing anti-aging interventions. This paper offers a detailed overview of major gene editing technologies (such as the CRISPR/Cas system, TALENs, and ZFNs) as well as emerging editing techniques (including base editing, prime editing, and epigenetic editing), describing their principles and applications. It also discusses research progress in areas such as constructing aging gene models, disease models, in vivo editing, and in vitro editing. Furthermore, it analyzes current technological challenges and proposes corresponding optimization strategies. Finally, it considers future directions for the development of gene editing technologies in aging research, including technological innovation and integrated multi-technology applications. Through these advances and innovations, gene editing is expected to play an increasingly important role in the anti-aging field, offering new strategies and methods to promote human health and longevity.