Influence of Liver Pathologies on the Development and Progression of Breast Cancer: Pathophysiological Mechanisms, Therapeutic Strategies and Prevention

This article analyzes the relationship between liver pathologies and breast cancer (BC). We consider the pathophysiological mechanisms underlying this relationship, including the influence of non-alcoholic fatty liver disease (NAFLD), drug-induced liver injury (DILI), and estrogen metabolism disorders. Particular attention is paid to the molecular pathways that contribute to the development of BC against the background of liver pathologies. An overview of modern therapeutic and preventive strategies for women with identified liver pathologies, as well as for women with liver pathologies and the first signs of BC is presented. The article describes drugs with confirmed efficacy based on international studies, and also provides recommendations on diet and regimen that help improve the prognosis of survival.