The Impact of Vitamin B12 Deficiency on Neurological Health Insights from Clinical Neurophysiology

Neurological and cognitive dysfunctions frequently occur as a result of Vitamin B12 deficiency which affects many individuals. The research investigates how Vitamin B12 supplements affect neurological health and cognitive abilities and life quality in patients who have Vitamin B12 deficiency. The research included 150 participants who were divided into two groups where 100 participants had Vitamin B12 deficiency and 50 participants served as controls. A comprehensive evaluation consisting of EMG, NCS, and VEP testing and MMSE, MoCA testing with SF-36 scale evaluation was performed at baseline and each time period from months three through twelve following the Vitamin B12 administration. The Vitamin B12 deficiency group participants demonstrated substantial neurological function recovery based on their improved motor unit potentials and nerve conduction velocities and VEP latency and amplitude results. The subjects achieved remarkable improvement with both their cognitive performance scores alongside their quality of life ratings. Vitamin B12 supplementation demonstrates its essential role in both restoring neurological function and enhancing cognitive health among patients who have Vitamin B12 deficiency by providing a promising therapeutic method to treat neurological impairments.

Authors

Publication Details

Journal
Journal of Neonatal Surgery
Published
2025-08-08
DOI
https://doi.org/10.63682/jns.v14i31s.8790
Primary Topic
Anesthesia and Neurotoxicity Research
Type
article
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article

The Impact of Vitamin B12 Deficiency on Neurological Health Insights from Clinical Neurophysiology

D Raghunandan
Journal of Neonatal Surgery
Anesthesia and Neurotoxicity Research
article

The Impact of Vitamin B12 Deficiency on Neurological Health Insights from Clinical Neurophysiology

D Raghunandan
article en

Abstract

Neurological and cognitive dysfunctions frequently occur as a result of Vitamin B12 deficiency which affects many individuals. The research investigates how Vitamin B12 supplements affect neurological health and cognitive abilities and life quality in patients who have Vitamin B12 deficiency. The research included 150 participants who were divided into two groups where 100 participants had Vitamin B12 deficiency and 50 participants served as controls. A comprehensive evaluation consisting of EMG, NCS, and VEP testing and MMSE, MoCA testing with SF-36 scale evaluation was performed at baseline and each time period from months three through twelve following the Vitamin B12 administration. The Vitamin B12 deficiency group participants demonstrated substantial neurological function recovery based on their improved motor unit potentials and nerve conduction velocities and VEP latency and amplitude results. The subjects achieved remarkable improvement with both their cognitive performance scores alongside their quality of life ratings. Vitamin B12 supplementation demonstrates its essential role in both restoring neurological function and enhancing cognitive health among patients who have Vitamin B12 deficiency by providing a promising therapeutic method to treat neurological impairments.

Journal of Neonatal SurgeryVol. 14(31S)
Responsible consumption and production
Openalex Percentile: Top 76%
Anesthesia and Neurotoxicity Research
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The Impact of Vitamin B12 Deficiency on Neurological Health Insights from Clinical Neurophysiology — D Raghunandan · Journal of Neonatal Surgery (2025) | TGRS Research Map | TGRS