Figure 3 from One-Carbon Metabolism Inhibition Depletes Purines and Results in Profound and Prolonged Ewing Sarcoma Growth Suppression
<p>Pharmacologic inhibition of one-carbon metabolism impairs Ewing sarcoma cell proliferation. <b>A–C,</b> Viability, measured using alamarBlue, of six Ewing sarcoma cell lines treated for 72 hours with increasing concentrations of SHIN1 (<b>A</b>), AGF347 (<b>B</b>), and PRTX (<b>C</b>). <b>D,</b> Colony-forming assay using five Ewing sarcoma cell lines treated for 2 weeks with the indicated inhibitors.</p>
Authors
- Larry H. Matherly (ORCID: https://orcid.org/0000-0001-6860-8133)
- David M. Loeb (ORCID: https://orcid.org/0000-0002-7319-5000)
- Antonio Di Cristofano (ORCID: https://orcid.org/0000-0003-2537-3228)
- Shrey Patel (ORCID: https://orcid.org/0009-0006-3444-4680)
- Noah Copperman
- Zhanjun Hou (ORCID: https://orcid.org/0000-0001-5631-5202)
- Sara Zirpoli (ORCID: https://orcid.org/0000-0002-8960-8463)
- A.R.W. Forrest (ORCID: https://orcid.org/0000-0003-0913-0111)
Publication Details
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1158/2767-9764.29858791
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00