Molecular Morphology of Telangiectatic Osteosarcoma Associated With Сystic Content: A Case Report

This case report is focused on a patient (a 32-year-old previously healthy man) with a femoral bone tissue tumor. The case underscores the diagnostic complexity of Telangiectatic Osteosarcoma (TOS) with Aneurysmal Bone Cystic (ABC) lesion and the importance of maintaining special immunohistochemical markers for differential diagnosis between low-grade osteosarcoma, primary ABC, and suspected TOS, which is a true mimicker of ABC. On the other hand, this presentation describes some molecular rearrangements seen in ABC.

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Publication Details

Journal
Cureus
Published
2025-08-08
DOI
https://doi.org/10.7759/cureus.89658
Primary Topic
Sarcoma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Molecular Morphology of Telangiectatic Osteosarcoma Associated With Сystic Content: A Case Report

David Makaridze, L Gogiashvili, Armaz Mariamidze, Giulia Ottaviani et al.
Cureus
Sarcoma Diagnosis and Treatment
article

Molecular Morphology of Telangiectatic Osteosarcoma Associated With Сystic Content: A Case Report

David Makaridze, L Gogiashvili, Armaz Mariamidze, Giulia Ottaviani, Tamuna Gvianishvili
article en

Abstract

This case report is focused on a patient (a 32-year-old previously healthy man) with a femoral bone tissue tumor. The case underscores the diagnostic complexity of Telangiectatic Osteosarcoma (TOS) with Aneurysmal Bone Cystic (ABC) lesion and the importance of maintaining special immunohistochemical markers for differential diagnosis between low-grade osteosarcoma, primary ABC, and suspected TOS, which is a true mimicker of ABC. On the other hand, this presentation describes some molecular rearrangements seen in ABC.

CureusVol. 17(8)
Tbilisi State University (GE), University of Milan (IT), David Tvildiani Medical University (GE)
Good health and well-being
Openalex Percentile: Top 69%
Sarcoma Diagnosis and Treatment
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