Not Your Typical Tumour: A Pediatric Dysgerminoma with an endocrine twist

Humoral Hypercalcemia of Malignancy (HHM) is commonly associated with adult cancers, including small cell carcinoma of the ovary and clear cell carcinoma of the ovary, and is rarely reported in pediatric malignancies. Here, we report a rare case of a 12-year-old girl with dysgerminoma with malignant hypercalcemia at diagnosis. She was managed with endocrinologist close monitoring with hydration. Oral steroid, calcitonin and Zoledronic acid. She showed a complete response on initiation of chemotherapy and underwent delayed excision after 4 cycles, unlike previously reported cases.

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Publication Details

Published
2025-08-11
DOI
https://doi.org/10.22541/au.175491748.83797720/v1
Primary Topic
Neuroendocrine Tumor Research Advances
Type
article
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article

Not Your Typical Tumour: A Pediatric Dysgerminoma with an endocrine twist

Manas Kalra, Swati Bhayana, Archana Arya, Aayush Gupta et al.
Neuroendocrine Tumor Research Advances
article

Not Your Typical Tumour: A Pediatric Dysgerminoma with an endocrine twist

Manas Kalra, Swati Bhayana, Archana Arya, Aayush Gupta, Anupam Sachdeva
article en

Abstract

Humoral Hypercalcemia of Malignancy (HHM) is commonly associated with adult cancers, including small cell carcinoma of the ovary and clear cell carcinoma of the ovary, and is rarely reported in pediatric malignancies. Here, we report a rare case of a 12-year-old girl with dysgerminoma with malignant hypercalcemia at diagnosis. She was managed with endocrinologist close monitoring with hydration. Oral steroid, calcitonin and Zoledronic acid. She showed a complete response on initiation of chemotherapy and underwent delayed excision after 4 cycles, unlike previously reported cases.

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Neuroendocrine Tumor Research Advances
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