Experimental Evidence Against Taurine Deficiency as a Driver of Aging in Humans
Taurine deficiency was recently proposed as a driver of aging in various species, including humans. To test this hypothesis, we assessed whether circulating taurine was associated with aging and physical performance in 137 physically inactive and physically active men aged 20-93. No association between circulating taurine levels and age, muscle mass, strength, physical performance, or mitochondrial function was observed, thereby challenging the implication of taurine deficiency as a primary driver of aging in humans.
Authors
- Rami Hammad
- Jean‐Philippe Leduc‐Gaudet (ORCID: https://orcid.org/0000-0002-7637-5445)
- Marina Cefis (ORCID: https://orcid.org/0000-0003-1898-4119)
- Vincent Marcangeli (ORCID: https://orcid.org/0000-0001-6413-2510)
- Gilles Gouspillou (ORCID: https://orcid.org/0000-0002-8543-3619)
- Richard Robitaille (ORCID: https://orcid.org/0000-0001-6628-0146)
- Jordan Granet
- José A. Morais (ORCID: https://orcid.org/0000-0001-9366-6626)
- Mylène Aubertin‐Leheudre (ORCID: https://orcid.org/0000-0002-6796-6710)
- Pierrette Gaudreau (ORCID: https://orcid.org/0000-0001-9362-2287)
- Marc Bélanger
Institutions
- University of Jordan (JO)
- Inserm (FR)
- Université du Québec à Montréal (CA)
- Université de Bourgogne (FR)
- McGill University Health Centre (CA)
- Institut Universitaire de Gériatrie de Montréal (CA)
- Centre for Interdisciplinary Research in Rehabilitation (CA)
- Group for Research in Decision Analysis (CA)
- Quebec Rehabilitation Research Network (CA)
- Christie (Canada) (CA)
- Centre Hospitalier de l’Université de Montréal (CA)
- McGill University (CA)
- Université du Québec à Trois-Rivières (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Aging Cell
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1111/acel.70191
- Citations
- 3
- Primary Topic
- Aldose Reductase and Taurine
- Type
- article
- Field-Weighted Citation Impact
- 3.45
Funders
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Fonds de Recherche du Québec - Santé