Clonal divergence and genomic meltdown in prostatic pleomorphic giant cell adenocarcinoma
Our study provides the first molecular roadmap of prostatic PGCA to date, establishing a novel five-gene prognostic signature and revealing fundamental insights into its pathogenesis through divergent evolution from conventional adenocarcinoma. These insights offer new opportunities for precise diagnosis, prognostic stratification, and targeted therapeutic strategies for this lethal prostate cancer variant.
Authors
- Changyin Feng (ORCID: https://orcid.org/0000-0002-6561-0606)
- Xiaoshi Ma
- Jizhou Gou
- Kaipeng Huang (ORCID: https://orcid.org/0000-0003-2269-0383)
- Jing Zhang (ORCID: https://orcid.org/0000-0002-4530-6754)
- Hongying Zhang (ORCID: https://orcid.org/0000-0003-1108-3078)
- Kun Chen (ORCID: https://orcid.org/0000-0003-4231-4502)
- Jiping Luo
- Xianlin Meng
- Wanying Li (ORCID: https://orcid.org/0000-0001-9705-394X)
- Xia Zhao (ORCID: https://orcid.org/0000-0002-4791-8172)
- Danni Liu (ORCID: https://orcid.org/0000-0002-7999-716X)
- Zhiqiang Cheng (ORCID: https://orcid.org/0000-0002-4371-0104)
- Lipeng Chen (ORCID: https://orcid.org/0000-0003-2169-2766)
- Liming Liu (ORCID: https://orcid.org/0009-0003-1691-670X)
- Yin Li (ORCID: https://orcid.org/0000-0001-8203-1123)
Institutions
- Sun Yat-sen University (CN)
- Southern University of Science and Technology (CN)
- Shenzhen Bioeasy Biotechnology (China) (CN)
- Fifth Tianjin Central Hospital (CN)
- Jiangsu Cancer Hospital (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Sun Yat-sen University Cancer Center (CN)
- Shenzhen Second People's Hospital (CN)
- Shenzhen Third People’s Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-12
- DOI
- https://doi.org/10.3389/fimmu.2025.1609340
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00