Gingipains disrupt bone homeostasis via dual regulation of osteogenesis and osteoclastogenesis through exosomal miR-146a-5p/TRAF6 signaling
Gingipains disrupt bone metabolism by inhibiting BMSCs osteogenesis and promoting osteoclastogenesis through communication via exosomes. Targeting miR-146a-5p offers a potential therapeutic approach to counter gingipain-induced periodontal destruction.
Authors
- Wei Zhou (ORCID: https://orcid.org/0000-0001-5527-3776)
- Huiwen Chen (ORCID: https://orcid.org/0000-0001-5269-2334)
- Kecong Zhou
- Huanyu Zhang (ORCID: https://orcid.org/0000-0001-6480-2510)
- Yue Liao (ORCID: https://orcid.org/0000-0002-1370-7334)
- Zhongchen Song
- Jiachen Dong (ORCID: https://orcid.org/0000-0002-6476-9180)
- Mengjun Sun
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Stomatological Hospital (CN)
- Shanghai Ninth People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-08-12
- DOI
- https://doi.org/10.3389/fcimb.2025.1614126
- Citations
- 1
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Shanghai Jiao Tong University
- School of Medicine, Shanghai Jiao Tong University
- National Key Research and Development Program of China