Figure 2 from Collagen XVII Promotes Pancreatic Ductal Adenocarcinoma Tumor Growth through Regulation of PIK3R5

<p>Hemidesmosome components integrin β4, integrin α6, and laminin-5 are not correlated with survival in patients with PDAC. <b>A,</b> Representative images of IHC staining of integrin β4, integrin α6, and laminin-5 in normal pancreas and PDAC tissues from 46 treatment-naïve patients with PDAC. Scale bars, 100 and 25 µm (inset). <b>B,</b><i>H</i>-score distribution of integrin β4 expression. <b>C,</b> Distribution of integrin α6 expression scores ranging from 1 to 3. <b>D,</b> Percentage of PDAC samples positive and negative for laminin-5. <b>E,</b> Kaplan–Meier survival analysis of high (<i>H</i>-score >131; <i>n</i> = 24) vs. low (<i>H</i>-score <131; <i>n</i> = 22) integrin β4–expressing patients with PDAC. <b>F,</b> Kaplan–Meier survival analysis of high (score >2; <i>n</i> = 14) vs. low (score ≤2; <i>n</i> = 32) integrin α6–expressing patients with PDAC. <b>G,</b> Kaplan–Meier survival analysis of positive (<i>n</i> = 19) vs. negative (<i>n</i> = 27) laminin-5–expressing patients with PDAC.</p>