Efficacy of P2Y12 receptor blockers: current approaches and prospects

The review is devoted to current methods for evaluating the efficacy of P2Y 12 receptor blockers in patients with coronary artery disease. Literature and original data are presented. Currently existing genetic and functional tests are insufficient for reliable diagnosis of resistance to P2Y 12 receptor blockers, which may be due to a number of concomitant factors, including inflammatory process. Proinflammatory markers can be studied to develop novel approaches to assessing the risk of thrombotic events during P2Y 12 receptor blocker therapy.