17.6% of patients in a German cohort with exocrine pancreatic cancer were diagnosed with a genetic tumor syndrome—a case for universal genetic testing?
These findings support ASCO and NCCN recommendations for germline testing in all PCA patients. We suggest offering large-panel genetic diagnostics early in clinical management, regardless of clinical parameters, with ongoing evaluation and adjustment of the gene panel.
Authors
- Karin Kast (ORCID: https://orcid.org/0000-0001-6531-755X)
- Michael Bitzer (ORCID: https://orcid.org/0000-0002-4463-8263)
- Daniel Hübschmann (ORCID: https://orcid.org/0000-0002-6041-7049)
- Thomas Kindler (ORCID: https://orcid.org/0000-0002-0383-0507)
- Stefan Fröhling (ORCID: https://orcid.org/0000-0001-7907-4595)
- Christoph E. Heilig (ORCID: https://orcid.org/0000-0001-8869-1421)
- Laura Gieldon (ORCID: https://orcid.org/0000-0002-8700-8616)
- Melanie Boerries (ORCID: https://orcid.org/0000-0002-3670-0602)
- F. Klauschen
- Karsten Spiekermann (ORCID: https://orcid.org/0000-0002-5139-4957)
- Jürgen Weitz (ORCID: https://orcid.org/0000-0002-5760-6391)
- M-V. Teleanu
- Daniel B. Lipka (ORCID: https://orcid.org/0000-0001-5081-7869)
- Gunnar Folprecht (ORCID: https://orcid.org/0000-0002-9321-9911)
- Marius Distler (ORCID: https://orcid.org/0000-0002-3164-5755)
- Arne Jahn (ORCID: https://orcid.org/0000-0003-1045-1908)
- Karl Hackmann (ORCID: https://orcid.org/0000-0003-4181-2120)
- Daniela Richter (ORCID: https://orcid.org/0009-0004-8958-140X)
- Katrin Pfütze
- Sebastian Bauer (ORCID: https://orcid.org/0000-0001-5949-8120)
- Barbara Hutter (ORCID: https://orcid.org/0000-0002-9034-0329)
- Joseph Porrmann (ORCID: https://orcid.org/0000-0001-8474-6309)
- Peter Horak (ORCID: https://orcid.org/0000-0003-4536-9306)
- Johannes Maximilian Wagner (ORCID: https://orcid.org/0000-0001-6890-4290)
- Evelin Schröck (ORCID: https://orcid.org/0000-0002-3377-1704)
- J. Fischer
- Pauline Wimberger (ORCID: https://orcid.org/0000-0002-7380-577X)
- Simon Kreutzfeldt (ORCID: https://orcid.org/0000-0003-3278-4586)
- Daniela Ellen Aust (ORCID: https://orcid.org/0000-0002-4867-8852)
- M. Franke
- Nagarajan Paramasivam (ORCID: https://orcid.org/0000-0002-7126-8472)
- Richard F. Schlenk (ORCID: https://orcid.org/0000-0003-2215-2059)
- A. Kübler
- C Meisel (ORCID: https://orcid.org/0000-0002-8201-6377)
- Benedikt Brors (ORCID: https://orcid.org/0000-0001-5940-3101)
- Christoph Kahlert (ORCID: https://orcid.org/0000-0003-4124-7918)
- W. Weichert
- Christoph Heining (ORCID: https://orcid.org/0000-0002-1256-8387)
- Hanno Glimm (ORCID: https://orcid.org/0000-0003-4104-1135)
- Mercedes Bermúdez (ORCID: https://orcid.org/0000-0002-6145-1134)
- Martina Fröhlich (ORCID: https://orcid.org/0000-0001-6760-7200)
- Ulrich Keilholz (ORCID: https://orcid.org/0000-0001-6773-9406)
- A. Stenzinger
- Doreen William (ORCID: https://orcid.org/0000-0001-7824-5073)
- Andreas Möck (ORCID: https://orcid.org/0000-0002-3332-9166)
- Ivo Buchhalter (ORCID: https://orcid.org/0000-0003-0764-5832)
- Jens Thomas Siveke (ORCID: https://orcid.org/0000-0002-8772-4778)
- Gustavo Baretton (ORCID: https://orcid.org/0000-0002-4051-6306)
- Klaus Schulze‐Osthoff (ORCID: https://orcid.org/0000-0003-1443-2720)
- Peter Schirmacher (ORCID: https://orcid.org/0000-0002-0950-3339)
- Tobias Herold (ORCID: https://orcid.org/0000-0002-9615-9432)
- Sebastian Uhrig (ORCID: https://orcid.org/0000-0002-0068-5957)
- Philipp J. Jost (ORCID: https://orcid.org/0000-0003-2454-0362)
- Anna Lena Illert
- Kristina Beck
- M. Arlt
Institutions
- University of Freiburg (DE)
- German Cancer Research Center (DE)
- Johannes Gutenberg University Mainz (DE)
- Medical University of Graz (AT)
- Heidelberg University (DE)
- University Medical Center Freiburg (DE)
- Helmholtz-Zentrum Dresden-Rossendorf (DE)
- University Hospital Heidelberg (DE)
- TUM Klinikum (DE)
- München Klinik Bogenhausen (DE)
- Humboldt-Universität zu Berlin (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- National Center for Tumor Diseases (DE)
- Institute of Human Genetics (PL)
- University Children's Hospital Tübingen (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- DKFZ-ZMBH Alliance (DE)
- Heidelberg Institute for Stem Cell Technology and Experimental Medicine (DE)
- West German Heart and Vascular Center Essen (DE)
- University Hospital Carl Gustav Carus (DE)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- University of Duisburg-Essen (DE)
- Technical University of Munich (DE)
- Technische Universität Dresden (DE)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- ESMO Gastrointestinal Oncology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1016/j.esmogo.2025.100218
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsches Krebsforschungszentrum
- Nationales Centrum für Tumorerkrankungen Heidelberg
- Deutschen Konsortium für Translationale Krebsforschung