Asymmetric Prins Cyclizations of O-Prenylated Salicylaldehydes
Abstract We report the asymmetric intramolecular Prins cyclization reactions of O-prenylated salicylaldehydes to 4-chromanols. Excellent efficiencies and selectivities were herein obtained using a highly fluorinated imino-imidodiphosphate (iIDP) Brønsted acid catalyst. The presented method tolerates substrates bearing both electron-donating and electron-withdrawing groups.
Authors
- Benjamin List (ORCID: https://orcid.org/0000-0002-9804-599X)
- Joyce A. A. Grimm (ORCID: https://orcid.org/0000-0003-3296-7761)
Institutions
- Max-Planck-Institut für Kohlenforschung (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Synthesis
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1055/a-2616-6753
- Primary Topic
- Synthetic Organic Chemistry Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Deutsche Forschungsgemeinschaft
- Max-Planck-Gesellschaft
- Horizon 2020 Framework Programme