Association Between Oxidative–Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case–Control Study

<b>Aim</b>: To assess oxidative-inflammatory biomarker prediction of incident CKD after 1-year follow-up in a population with overweight/obesity and metabolic syndrome. <b>Methods</b>: Prospective nested case-control study comprising 117 CKD incident cases and 117 matched controls free of CKD after 1-year follow-up conducted in 55-75-year-old participants. Controls were time-matched 1:1 to cases by intervention group, age (≤65 vs. >65 years), and sex. Serum creatinine (SCr), cystatin C (CyC), and urine albumin-to-creatinine ratio (UACR) were measured at baseline, and CKD Epidemiology Collaboration equations for Caucasians were used to assess SCr, CyC, and CyC-SCr-based estimated Glomerular Filtration Rate (eGFR). Baseline levels of malondialdehyde (MDA), carbonyls, tumour necrosis factor alpha (TNFα), interleukin (IL)-1β, IL-1ra, IL-6, monocyte chemoattractant protein 1 (MCP-1), and leptin were determined from fasting serum samples. An inflammatory-oxidative stress score based on these biomarkers was calculated. Incident CKD was defined by eGFR-SCr <60 mL/min/1.73 m<sup>2</sup>, and/or UACR ≥30 mg/g in the absence of CKD at baseline. <b>Results</b>: UACR positively correlated with pro-inflammatory markers (IL-1β; TNFα) and oxidative damage marker (MDA); eGFR-cyC showed negative correlations with IL-1β and IL-1ra, and eGFR-SCr with leptin. The odds ratios (OR; 95% CI) for incident CKD in the highest vs. the lowest tertile of IL-1ra IL-6 and TNFα were (2.22; 1.22-4.04), (7.03; 2.88-17.14), and (3.79; 1.79-8.02), respectively. The inflammatory-oxidative stress score was associated with incident CKD (OR per 1-SD increment: 2.06; 1.49-2.83). <b>Conclusions</b>: Inflammatory/oxidative stress is associated with CKD incidence in individuals with high cardiovascular risk, underscoring the importance in identify early inflammation to prevent this disease.

Authors

Institutions

Publication Details

Journal
Antioxidants
Published
2025-08-08
DOI
https://doi.org/10.3390/antiox14080975
Primary Topic
Chronic Kidney Disease and Diabetes
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Association Between Oxidative–Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case–Control Study

Josep A. Tur, Cristina Bouzas, José Manuel Santos‐Lozano, Jordi Salas‐Salvadó et al.
Antioxidants
Chronic Kidney Disease and Diabetes
article

Association Between Oxidative–Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case–Control Study

Josep A. Tur, Cristina Bouzas, José Manuel Santos‐Lozano, Jordi Salas‐Salvadó, Miguel Ruiz‐Canela, Andrés Díaz‐López, José López‐Miranda, Jesús Vioqué, Margalida Monserrat-Mesquida, Aurora Bueno‐Cavanillas, Dora Romaguera, Francisco José Tinahones, Antoni Sureda, Maria Magdalena Quetglas‐Llabrés, Sebastián Mas, Silvia García, Nancy Babió, Pilar Matía‐Martín, J. Alfredo Martínéz, M. Olga Garcia-Fernandez, Ramón Estruch
article en

Abstract

<b>Aim</b>: To assess oxidative-inflammatory biomarker prediction of incident CKD after 1-year follow-up in a population with overweight/obesity and metabolic syndrome. <b>Methods</b>: Prospective nested case-control study comprising 117 CKD incident cases and 117 matched controls free of CKD after 1-year follow-up conducted in 55-75-year-old participants. Controls were time-matched 1:1 to cases by intervention group, age (≤65 vs. >65 years), and sex. Serum creatinine (SCr), cystatin C (CyC), and urine albumin-to-creatinine ratio (UACR) were measured at baseline, and CKD Epidemiology Collaboration equations for Caucasians were used to assess SCr, CyC, and CyC-SCr-based estimated Glomerular Filtration Rate (eGFR). Baseline levels of malondialdehyde (MDA), carbonyls, tumour necrosis factor alpha (TNFα), interleukin (IL)-1β, IL-1ra, IL-6, monocyte chemoattractant protein 1 (MCP-1), and leptin were determined from fasting serum samples. An inflammatory-oxidative stress score based on these biomarkers was calculated. Incident CKD was defined by eGFR-SCr <60 mL/min/1.73 m<sup>2</sup>, and/or UACR ≥30 mg/g in the absence of CKD at baseline. <b>Results</b>: UACR positively correlated with pro-inflammatory markers (IL-1β; TNFα) and oxidative damage marker (MDA); eGFR-cyC showed negative correlations with IL-1β and IL-1ra, and eGFR-SCr with leptin. The odds ratios (OR; 95% CI) for incident CKD in the highest vs. the lowest tertile of IL-1ra IL-6 and TNFα were (2.22; 1.22-4.04), (7.03; 2.88-17.14), and (3.79; 1.79-8.02), respectively. The inflammatory-oxidative stress score was associated with incident CKD (OR per 1-SD increment: 2.06; 1.49-2.83). <b>Conclusions</b>: Inflammatory/oxidative stress is associated with CKD incidence in individuals with high cardiovascular risk, underscoring the importance in identify early inflammation to prevent this disease.

AntioxidantsVol. 14(8)
Madrid Institute for Advanced Studies (ES), Universidad de Valladolid (ES), Universitat de Miguel Hernández d'Elx (ES), Instituto de Salud Carlos III (ES), Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES), Instituto Maimónides de Investigación Biomédica de Córdoba (ES), Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (ES), Institut de Recerca Biomèdica Catalunya Sud (ES), Instituto de Investigación Biosanitaria de Granada (ES), Health Research Institute of the Balearic Islands (ES), Hospital Universitario Fundación Jiménez Díaz (ES), Research Institute of Health Sciences (ES), Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES), Hospital Clínico Universitario Virgen de la Victoria (ES), Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES), Instituto de Investigación Biomédica de Málaga (ES), Universitat de les Illes Balears (ES), University of Córdoba (ES), Universitat Rovira i Virgili (ES), Universidad Autónoma de Madrid (ES), Universidad de Sevilla (ES), Universidad de Navarra (ES), Universidad de León (ES)
Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, European Regional Development Fund
Openalex Percentile: Top 78%
Chronic Kidney Disease and Diabetes
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.