Lung-brain axis-generated inflammatory biomarkers in traumatic brain injury and acute respiratory distress syndrome: Role of mechanical ventilation/stress
These results highlight overlapping innate immunity dysregulation as a manifestation of lung-brain axis disruption in both TBI- and ARDS-exposed subjects with amplified dysregulation with mechanical ventilation. Additional longitudinal studies of well-phenotyped TBI and ARDS subjects may substantiate the prognostic value of biomarker analyses in assessing the severity of bidirectional lung-brain axis injuries.
Authors
- Nancy G. Casanova (ORCID: https://orcid.org/0000-0002-6363-2414)
- Sam White (ORCID: https://orcid.org/0000-0001-9374-3492)
- Sara M. Camp
- Joe G. N. Garcia (ORCID: https://orcid.org/0000-0002-6934-0420)
- Juan Pablo de Rivero Vaccari (ORCID: https://orcid.org/0000-0002-5460-8834)
- Bellal A Joseph (ORCID: https://orcid.org/0000-0002-2205-3061)
- Nathan H. Johnson (ORCID: https://orcid.org/0000-0002-4857-2273)
- Jon Pérez Bárcena
Institutions
- Scripps Research Institute (US)
- University of Arizona (US)
- University of Miami (US)
- Hospital Universitario Son Espases (ES)
- Neurological Surgery (US)
Publication Details
- Journal
- Advances in Biomarker Sciences and Technology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.abst.2025.08.002
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00