Narirutin mitigates inflammatory arthritis and osteoporosis through modulating macrophage phenotype and osteoclastogenesis
These findings highlight the potential of targeting macrophage pro-inflammatory M1 phenotype in and osteoclastogenesis as an <i>effective</i> strategy for inflammatory arthritis and systemic osteoporosis, and positioning NRT may serve as a promising therapeutic drug candidate.
Authors
- Chengyao Lu
- Yuhu Zhao
- Xiaole Peng (ORCID: https://orcid.org/0000-0002-5472-9468)
- Wei Lü (ORCID: https://orcid.org/0000-0002-1333-0274)
- Xiaoheng Lu
- Dechun Geng (ORCID: https://orcid.org/0000-0003-4375-2803)
- Qiuju Sheng (ORCID: https://orcid.org/0000-0001-6683-9309)
- Q. Wang
- Hao Xu (ORCID: https://orcid.org/0000-0003-2598-4010)
- Yaozeng Xu
- Xiaomin Lu (ORCID: https://orcid.org/0000-0001-6798-2668)
- Qing Wang (ORCID: https://orcid.org/0009-0009-7455-1343)
Institutions
- Nantong University (CN)
- Soochow University (CN)
- Affiliated Hospital of Nantong University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- First Affiliated Hospital of Soochow University (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1016/j.jot.2025.07.008
- Citations
- 2
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.61