Targeting Ferroptosis Restores the Antiviral Activity of CD8+ T Cells During Chronic Hepatitis B Virus Infection
Our study demonstrates that ferroptosis drives CD8<sup>+</sup> T-cell dysfunction in chronic HBV infection. Targeting ferroptosis pathways may offer a novel therapeutic strategy to restore antiviral immunity.
Authors
- Huajun Zhao (ORCID: https://orcid.org/0000-0001-6619-8329)
- Haohao Li (ORCID: https://orcid.org/0000-0002-0171-1205)
- Xin Lan (ORCID: https://orcid.org/0000-0003-1741-7091)
- C.Y. Huo (ORCID: https://orcid.org/0009-0004-9666-6380)
- Qiuju Han (ORCID: https://orcid.org/0000-0002-6511-2308)
- Shasha Yang (ORCID: https://orcid.org/0000-0002-6646-5332)
- Shi Li-zhi
- Jun Wang (ORCID: https://orcid.org/0000-0002-6346-2929)
- Jian Zhang (ORCID: https://orcid.org/0000-0002-1725-0466)
- Zhuo Li (ORCID: https://orcid.org/0000-0002-9937-2669)
- Meng-Hua Li (ORCID: https://orcid.org/0009-0006-3215-847X)
- Su Xiao
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Shandong University (CN)
- The Fourth People's Hospital of Zibo City (CN)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101612
- Citations
- 5
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 7.59