Magnetoelectric nanoparticle technology for mitigating motor deficits in Parkinsonian mice
MENP-based STh-DBS can counteract behavioral disturbances caused by impaired neural circuits following extensive dopaminergic cell loss in PD mice. Additionally, no adverse effects or loss of efficacy were observed over time for up to 18 months with respect to astro- and microgliosis. While effective modulation was only achieved with a higher magnetic coil configuration, this finding represents a critical step toward refining MENP-based neuromodulation in PD.
Authors
- Daniëlle Mulder-Jongen
- Mario Ries
- Yasin Temel (ORCID: https://orcid.org/0000-0002-3589-5604)
- Kristen Kozielski (ORCID: https://orcid.org/0000-0003-3504-2318)
- David Dominguez-Paredes (ORCID: https://orcid.org/0000-0002-9033-7285)
- Aleksandra Milojkovic
- Prachi Kumari (ORCID: https://orcid.org/0000-0003-0669-2338)
- Ali Jahanshahi (ORCID: https://orcid.org/0000-0002-7451-3461)
Institutions
- Royal Netherlands Academy of Arts and Sciences (NL)
- Maastricht University Medical Centre (NL)
- Maastricht University (NL)
- Technical University of Munich (DE)
Publication Details
- Journal
- Brain stimulation
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1016/j.brs.2025.08.008
- Citations
- 3
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.17