Quercetin attenuates tendon stem/progenitor cell senescence and promotes aged tendon repair via AKT/NF-κB/NLRP3-mediated mitophagy activation
Our findings suggest quercetin could alleviate senescent phenotypes in TSPCs through AKT-mediated mitochondrial stabilization and SASP suppression. The DPH@QUE delivery system enables effective translation of these anti-aging effects into functional tendon regeneration, providing a novel therapeutic strategy for aging tendon injury.
Authors
- Yingjuan Li (ORCID: https://orcid.org/0000-0002-5580-1003)
- Panpan Lu (ORCID: https://orcid.org/0000-0002-9751-2947)
- Liu Shi (ORCID: https://orcid.org/0000-0002-8990-4019)
- Yucheng Gao
- Mingzhang
- Guang-Chun Dai (ORCID: https://orcid.org/0000-0003-1440-4850)
- Wenguo Cui (ORCID: https://orcid.org/0000-0002-6938-9582)
- Renwang Sheng (ORCID: https://orcid.org/0009-0004-8803-5343)
- Cheng Zhang (ORCID: https://orcid.org/0000-0003-3843-1562)
- Hao Wang (ORCID: https://orcid.org/0000-0002-9971-1237)
- Xiaoyu Liu (ORCID: https://orcid.org/0000-0002-0545-3055)
- Yunfeng Rui (ORCID: https://orcid.org/0000-0001-9019-5531)
- Mu‐Min Cao
Institutions
- Shanghai Jiao Tong University (CN)
- Zhongda Hospital Southeast University (CN)
- Southeast University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1016/j.jare.2025.08.013
- Citations
- 3
- Primary Topic
- Tendon Structure and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.16