Is early-phase amyloid PET ready for use as neurodegeneration marker?

Alzheimer's disease is marked by accumulation of amyloid-β (Aβ) and abnormal tau, associated with subsequent neurodegeneration. Validated markers of neurodegeneration include brain glucose metabolism, perfusion and atrophy. Dual-phase amyloid PET imaging allows to assess both Aβ buildup and perfusion changes through a single tracer injection. Increasing evidence supports the comparability of early-phase amyloid PET scans and glucose metabolism changes assessed by ¹⁸F-FDG PET at group and individual levels, regardless of the amyloid tracers and the disease, emphasizing the added value of dual-phase amyloid PET imaging protocols for clinical and research settings.