Trimethylamine- <i>N</i> -Oxide Affects Cell Type–Specific Pathways and Networks in Mouse Aorta to Promote Atherosclerotic Plaque Vulnerability
Our results reveal the effects of TMAO on vSMCs to promote apoptosis and decrease ECM formation and on macrophage-mediated ECM degradation to, in concert enhance atherosclerotic plaque instability.
Authors
- Diana M. Shih (ORCID: https://orcid.org/0000-0002-2848-3492)
- Brian J. Bennett (ORCID: https://orcid.org/0000-0002-0766-3195)
- Maggie Han (ORCID: https://orcid.org/0000-0002-1370-3456)
- Hua Cai (ORCID: https://orcid.org/0000-0001-8747-6156)
- Zhiqiang Zhou (ORCID: https://orcid.org/0000-0002-8914-0864)
- Aldons Jake Lusis (ORCID: https://orcid.org/0000-0001-9013-0228)
- Michael Cheng (ORCID: https://orcid.org/0000-0002-7841-3740)
- Ingrid Cely
- Zeneng Wang (ORCID: https://orcid.org/0000-0002-6455-8228)
- Stanley L. Hazen (ORCID: https://orcid.org/0000-0001-7124-6639)
- Jenny Cheng (ORCID: https://orcid.org/0009-0009-2248-1697)
- Graciel Diamante (ORCID: https://orcid.org/0000-0002-2433-6161)
- Sasha Gladkikh
- Hooman Allayee (ORCID: https://orcid.org/0000-0002-2384-5239)
- Xia Yang (ORCID: https://orcid.org/0000-0002-3971-038X)
- Victor Wei Zhang (ORCID: https://orcid.org/0000-0002-7335-1472)
- Yu-Chen Wang (ORCID: https://orcid.org/0000-0002-0690-2422)
- Satyesh K. Sinha (ORCID: https://orcid.org/0000-0002-8735-6303)
- In Sook Ahn
- Rubani Chugh
Institutions
- QB3 (US)
- Cleveland Clinic (US)
- University of California, Los Angeles (US)
- Cleveland Clinic Lerner College of Medicine (US)
- Heart Foundation (US)
- Quantitative BioSciences (US)
- Center for Human Genetics (US)
- Institute of Human Genetics (PL)
- Anna Needs Neuroblastoma Answers (US)
- Hi-Z Technology (United States) (US)
- Yo San University (US)
- Cellular Research (United States) (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1161/atvbaha.125.323047
- Citations
- 1
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 1.16