Trimethylamine- <i>N</i> -Oxide Affects Cell Type–Specific Pathways and Networks in Mouse Aorta to Promote Atherosclerotic Plaque Vulnerability

Our results reveal the effects of TMAO on vSMCs to promote apoptosis and decrease ECM formation and on macrophage-mediated ECM degradation to, in concert enhance atherosclerotic plaque instability.

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Publication Details

Journal
Arteriosclerosis Thrombosis and Vascular Biology
Published
2025-08-14
DOI
https://doi.org/10.1161/atvbaha.125.323047
Citations
1
Primary Topic
Diet and metabolism studies
Type
article
Field-Weighted Citation Impact
1.16
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article

Trimethylamine- N -Oxide Affects Cell Type–Specific Pathways and Networks in Mouse Aorta to Promote Atherosclerotic Plaque Vulnerability

Diana M. Shih, Brian J. Bennett, Maggie Han, Hua Cai et al.
1 citations
Arteriosclerosis Thrombosis and Vascular Biology
Diet and metabolism studies
1.16
article

Trimethylamine- N -Oxide Affects Cell Type–Specific Pathways and Networks in Mouse Aorta to Promote Atherosclerotic Plaque Vulnerability

Diana M. Shih, Brian J. Bennett, Maggie Han, Hua Cai, Zhiqiang Zhou, Aldons Jake Lusis, Michael Cheng, Ingrid Cely, Zeneng Wang, Stanley L. Hazen, Jenny Cheng, Graciel Diamante, Sasha Gladkikh, Hooman Allayee, Xia Yang, Victor Wei Zhang, Yu-Chen Wang, Satyesh K. Sinha, In Sook Ahn, Rubani Chugh
article en
1 citations

Abstract

Our results reveal the effects of TMAO on vSMCs to promote apoptosis and decrease ECM formation and on macrophage-mediated ECM degradation to, in concert enhance atherosclerotic plaque instability.

Arteriosclerosis Thrombosis and Vascular BiologyVol. 45(10)
QB3 (US), Cleveland Clinic (US), University of California, Los Angeles (US), Cleveland Clinic Lerner College of Medicine (US), Heart Foundation (US), Quantitative BioSciences (US), Center for Human Genetics (US), Institute of Human Genetics (PL), Anna Needs Neuroblastoma Answers (US), Hi-Z Technology (United States) (US), Yo San University (US), Cellular Research (United States) (US)
Openalex Percentile: Top 19%
Diet and metabolism studies
1.16
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