Intrathecal injections of non-peptide oxytocin receptor agonists, WAY 267,464 and TC OT 39, induce significant anti-hyperalgesia in both male and female rats with inflammatory pain.
These compounds induced significant anti-hyperalgesia without any sex differences, suggesting that the inhibition of IRAP degradation eliminated the variation in oxytocin's effects based on sex. Therefore, we propose these compounds as promising candidates for treating inflammatory hyperalgesia in clinical applications.
Authors
- Lok‐Hi Chow (ORCID: https://orcid.org/0000-0003-4228-8068)
- Yuan-Hao Chen (ORCID: https://orcid.org/0000-0002-0570-4328)
- Pin-Chen Lin
- Ying-Jie Chen (ORCID: https://orcid.org/0000-0003-2754-8909)
- E. Huang (ORCID: https://orcid.org/0000-0003-4263-8195)
Institutions
- University of Taipei (TW)
- Taipei Veterans General Hospital (TW)
- National Defense Medical Center (TW)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.22038/ijbms.2025.86093.18615
- Primary Topic
- Neuroendocrine regulation and behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science and Technology Council