Anti‐Metastatic Effects of Aprepitant on Glioblastoma Cells: Targeting the Substance P/Neurokinin‐1 Pathway
These findings underscore the potent anti-metastatic and anti-angiogenic effects of NK-1R antagonism in glioblastoma and highlight aprepitant as a promising candidate for future in vivo and in ovo therapeutic investigations targeting extracellular matrix (ECM) remodeling, chemotaxis, and angiogenesis.
Authors
- Elif Kaya Tilki (ORCID: https://orcid.org/0000-0003-2122-5324)
- Selin Engür (ORCID: https://orcid.org/0000-0003-1534-8117)
- Miriş Dikmen (ORCID: https://orcid.org/0000-0002-9856-3148)
Institutions
- Anadolu University (TR)
- Eskişehir City Hospital (TR)
- Pamukkale University (TR)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/cam4.71148
- Citations
- 2
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Anadolu Üniversitesi