Autophagy inhibitors block pathogenic NET release in immune-mediated inflammatory disease without impairing host defence
We propose that autophagy signalling pathways represent novel and exciting targets for the development of small molecule therapeutics to block unwanted neutrophil activation and NET release in immune-mediated inflammatory disease.
Authors
- Patrick A. Eyers (ORCID: https://orcid.org/0000-0002-9220-2966)
- Zoe McLaren
- Michele Fresneda Alarcon (ORCID: https://orcid.org/0000-0002-3566-9244)
- Christina Linford
- Daniel M. Foulkes (ORCID: https://orcid.org/0000-0002-1021-6740)
- Emma Fairweather (ORCID: https://orcid.org/0000-0002-8029-6571)
- Helen L. Wright (ORCID: https://orcid.org/0000-0003-0442-3134)
- A. Nolan (ORCID: https://orcid.org/0000-0001-5514-8414)
- Andrew Sellin (ORCID: https://orcid.org/0000-0001-7670-9882)
Institutions
- University of Liverpool (GB)
- Aintree University Hospitals NHS Foundation Trust (GB)
- Systems Biology Institute (JP)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1093/rheumatology/keaf437
- Citations
- 3
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- Liverpool University Hospitals NHS Foundation Trust