Development of blood culture time-to-positivity as a pharmacodynamic indicator for monitoring antibiotic therapy against MDR Gram-negative bacteria
Tpos is a simple, reproducible marker of serum antibiotic activity against ESBL- and carbapenemase-producing K. pneumoniae. With further clinical validation, Tpos could be developed as a complementary surrogate marker for early detection of inadequate antimicrobial therapy in patients receiving antibiotic therapy for bloodstream infections caused by MDR Gram-negative bacteria.
Authors
- Martina Brandolini (ORCID: https://orcid.org/0009-0002-1558-032X)
- Claudia Colosimo (ORCID: https://orcid.org/0009-0001-4135-9402)
- Irene Zaghi
- Sofia Montanari (ORCID: https://orcid.org/0000-0001-7342-980X)
- Vittorio Sambri (ORCID: https://orcid.org/0000-0002-5012-7355)
- Russell E. Lewis (ORCID: https://orcid.org/0000-0002-2002-4339)
- Monica Cricca (ORCID: https://orcid.org/0000-0002-2815-3119)
Institutions
- University of Padua (IT)
- The University of Queensland (AU)
- Royal Brisbane and Women's Hospital (AU)
- University Hospital Galway (IE)
- Azienda Unità Sanitaria Locale Della Romagna (IT)
- Université de Nîmes (FR)
- University of Bologna (IT)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1093/jac/dkaf276
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00