Causal Central Network Remodeling in Diabetic Neuropathy: An Integrated MR-fMRI Study

This study establishes DPN as a CNS-periphery integrated network disorder: genetic drivers disrupt default mode-visual integration, while compensatory subcortical-cerebellar hyperconnectivity stabilizes motor function via adaptive mechanisms. The LSFG emerges as a neuroadaptive hub, where elevated ALFF and connectivity reorganization (↓lingual gyrus/↑precuneus) reflect dynamic rebalancing between impaired basic vision and enhanced visuospatial processing. These findings redefine DPN pathogenesis beyond pure peripheral neurodegeneration, providing a theoretical foundation for early detection and circuit-targeted neuromodulation therapies.