Cortical bone status and its determinants in pediatric Klinefelter syndrome
Cortical bone accumulation, evaluated through DXR, is only slightly reduced in pediatric KS. Advanced age and lower circulating 25-OHD emerged as clinical risk factors for a lower BHI. BHI Z-scores were not associated with the D2:D4 ratio or LS BMD Z-scores. Therefore, BHI Z-scores are inapt to predict LS BMD Z-scores, though their potential to predict fractures warrants further study.
Authors
- Willem Staels (ORCID: https://orcid.org/0000-0001-8259-3329)
- Ellen Anckaert (ORCID: https://orcid.org/0000-0003-2861-1201)
- Elise Nauwynck (ORCID: https://orcid.org/0000-0001-9136-9126)
- Jean De Schepper (ORCID: https://orcid.org/0000-0002-2999-0250)
- Jesse Vanbesien (ORCID: https://orcid.org/0000-0001-8817-6139)
- Caroline Ernst (ORCID: https://orcid.org/0000-0003-3188-741X)
- Inge Gies (ORCID: https://orcid.org/0000-0002-8571-0858)
- Inneke Willekens (ORCID: https://orcid.org/0000-0003-3345-4431)
- Maartje Hickmann (ORCID: https://orcid.org/0009-0003-4230-3157)
Institutions
- Vrije Universiteit Brussel (BE)
- Universitair Ziekenhuis Brussel (BE)
Publication Details
- Journal
- Endocrine Connections
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1530/ec-25-0216
- Citations
- 1
- Primary Topic
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Type
- article
- Field-Weighted Citation Impact
- 1.82