Fifth edition WHO classification: mature B-cell neoplasms

We present a review of mature B-cell neoplasms as described in the fifth edition of the WHO classification of haematolymphoid tumours (WHO-HAEM5). Entities have expanded, and definitions are increasingly reliant on genomic and other technologies. However, the WHO-HAEM5 employs a hierarchical structure with family (class)-level definitions that group several specific entities. This approach enables the assignment of a family-level diagnosis when criteria for specific entities cannot be met due to resource constraints. To facilitate application in resource-limited settings, WHO-HAEM5 divides diagnostic criteria into 'essential' and desirable criteria for most entities. This review focuses on changes and updates in B-cell lymphoma classification, providing guidance on how to apply the WHO classification in resource-limited settings.

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Publication Details

Journal
Journal of Clinical Pathology
Published
2025-08-12
DOI
https://doi.org/10.1136/jcp-2025-210260
Citations
1
Primary Topic
Lymphoma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
1.47
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Fifth edition WHO classification: mature B-cell neoplasms

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Fifth edition WHO classification: mature B-cell neoplasms

Ming‐Qing Du, John K. C. Chan, Sumeet Gujral, Kikkeri N. Naresh, Stefano Lazzi, Wah Cheuk, Lorenzo Leoncini, Shahin Sayed, German Ott, Kennosuke Karube, Aliyah R. Sohani, Anita Borges
article en
1 citations

Abstract

We present a review of mature B-cell neoplasms as described in the fifth edition of the WHO classification of haematolymphoid tumours (WHO-HAEM5). Entities have expanded, and definitions are increasingly reliant on genomic and other technologies. However, the WHO-HAEM5 employs a hierarchical structure with family (class)-level definitions that group several specific entities. This approach enables the assignment of a family-level diagnosis when criteria for specific entities cannot be met due to resource constraints. To facilitate application in resource-limited settings, WHO-HAEM5 divides diagnostic criteria into 'essential' and desirable criteria for most entities. This review focuses on changes and updates in B-cell lymphoma classification, providing guidance on how to apply the WHO classification in resource-limited settings.

Journal of Clinical PathologyVol. 78(11)
University of Siena (IT), Harvard University (US), University of Washington (US), University of Cambridge (GB), Aga Khan University Hospital Nairobi (KE), Tata Memorial Hospital (IN), Robert Bosch Hospital (DE), Massachusetts General Hospital (US), Fred Hutch Cancer Center (US), Aga Khan University Nairobi (KE), Queen Elizabeth Hospital (CN), Nagoya University (JP)
Openalex Percentile: Top 16%
Lymphoma Diagnosis and Treatment
1.47
DOIOpen Access PDFOpenAlex
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