Predicting sacral insufficiency fractures in carbon ion therapy for sacral chordoma: The role of RBE‐weighted dose, dose‐averaged LET, and volume
Exposure of sacral bone to high-dose radiation with LET<sub>d</sub> values of the order of 40 keV/µm emerged as a significant predictor of SIF development. Further validation on larger patient cohorts is warranted to refine individual risk stratification and to inform safer LET<sub>d</sub>-based treatment planning.
Authors
- Silvia Molinelli (ORCID: https://orcid.org/0000-0002-5548-3949)
- Marco Rotondi (ORCID: https://orcid.org/0000-0001-7730-9776)
- Elettra Ferrari
- Matteo Bagnalasta (ORCID: https://orcid.org/0009-0002-3566-5179)
- Agnieszka Chalaszczyk (ORCID: https://orcid.org/0000-0003-4881-2422)
- Giuseppe Magro (ORCID: https://orcid.org/0000-0001-7140-8642)
- Stefania Russo (ORCID: https://orcid.org/0000-0003-0114-8042)
- Sara Imparato (ORCID: https://orcid.org/0000-0001-6122-5877)
- Maria Rosaria Fiore (ORCID: https://orcid.org/0000-0001-9650-9036)
- Ester Orlandi (ORCID: https://orcid.org/0000-0003-1588-3558)
- Mario Ciocca (ORCID: https://orcid.org/0000-0001-9888-9589)
Institutions
- University of Pavia (IT)
- National Center for Oncological Hadrontherapy (IT)
Publication Details
- Journal
- Medical Physics
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/mp.18045
- Citations
- 1
- Primary Topic
- Bone Tumor Diagnosis and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.67