Microbiota Transplant Therapy Is Safe and Feasible in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a complex inflammatory disease that the gut microbiome likely contributes to and may be a potential therapeutic avenue for nontoxically improving outcomes. Here, we show that microbiota transplant therapy (MTT) is safe and feasible. The MTT regimen achieves only modest levels of donor microbiota engraftment but is accompanied by a transient reduction in circulating pro-inflammatory cytokines. These findings of decreased systemic inflammation with only modest donor engraftment support the potential of MTT as a novel treatment for PAH. (Microbiota Transplant Therapy for Pulmonary Arterial Hypertension: Early Safety and Feasibility Study; NCT04884971).
Authors
- Madelyn L. Blake (ORCID: https://orcid.org/0000-0002-6802-9470)
- Daphne Moutsoglou (ORCID: https://orcid.org/0000-0002-4071-3756)
- Thenappan Thenappan (ORCID: https://orcid.org/0000-0002-6210-0467)
- Sasha Z. Prisco (ORCID: https://orcid.org/0000-0002-9059-0635)
- Alexander Khoruts (ORCID: https://orcid.org/0000-0002-3205-3188)
- Kurt W. Prins (ORCID: https://orcid.org/0000-0002-0364-6742)
- Amanda J. Kabage (ORCID: https://orcid.org/0000-0003-3519-7416)
- Dina C Belhasan (ORCID: https://orcid.org/0009-0003-0200-7708)
- Boah Vang
- Gretchen Peichel
- Sharon Lopez (ORCID: https://orcid.org/0000-0002-1744-4447)
- Ε. Kenneth Weir
- B. Kremer
Institutions
- University of Minnesota (US)
- Minneapolis VA Health Care System (US)
Publication Details
- Journal
- JACC Basic to Translational Science
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1016/j.jacbts.2025.101347
- Citations
- 2
- Primary Topic
- Transplantation: Methods and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- American Heart Association
- National Institutes of Health