Real-Life Implementation of Guideline-Recommended Medical Therapy in Heart Failure with Reduced Ejection Fraction: Effects on Prognosis and Left Ventricular Ejection Fraction. Primary results of TITRATE-HF
These findings highlight the importance of early and intensive GRMT implementation, and emphasize the need for continuous dose titration beyond the initial phase to improve LVEF and clinical outcomes.
Authors
- Julio E C van de Swaluw
- Loek van Heerebeek (ORCID: https://orcid.org/0000-0001-6718-2871)
- Jasper J. Brugts (ORCID: https://orcid.org/0000-0002-5522-9318)
- Rudolf A. de Boer (ORCID: https://orcid.org/0000-0002-4775-9140)
- Gerard C.M. Linssen (ORCID: https://orcid.org/0000-0002-3339-1955)
- Nikola Faber
- Hans‐Peter Brunner‐La Rocca (ORCID: https://orcid.org/0000-0002-4356-8566)
- Robert N. Denham
- Ron Pisters (ORCID: https://orcid.org/0000-0001-8965-0664)
- Stefan Koudstaal (ORCID: https://orcid.org/0000-0003-4982-6658)
- Jishnu Malgie (ORCID: https://orcid.org/0009-0001-1561-3542)
- Clara E.E. van Ofwegen
- Carlos A da Fonseca
- Henk P. Swart
- Ayten Yilmaz
- Mariëlle I Wilde
Institutions
- Fryske Akademy (NL)
- Maastricht University Medical Centre (NL)
- Medisch Centrum Leeuwarden (NL)
- Maastricht University (NL)
- St. Antonius Ziekenhuis (NL)
- OLVG (NL)
- Diakonessenhuis hospital (NL)
- Beatrix Kinderziekenhuis (NL)
- Groene Hart Ziekenhuis (NL)
- Ziekenhuis Groep Twente (NL)
- Erasmus MC Cancer Institute (NL)
- Admiraal De Ruyter Ziekenhuis (NL)
- Rijnstate Hospital (NL)
- Ziekenhuis Bernhoven (NL)
- Bravis Ziekenhuis (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- European Journal of Heart Failure
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1002/ejhf.70006
- Citations
- 2
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- AstraZeneca
- Dutch Cardiovascular Alliance
- ZonMw
- Vifor Pharma
- ICIN Netherlands Heart Institute
- Netherlands Heart Institute